What this means
This review pulls together recent work on sirtuins, proteins linked to aging and brain disease. It does not show that changing sirtuin levels would prevent or treat Alzheimer's.
Plain-English summary written by an AI model from the abstract. The original is below.
- Who it was tested in
- A review of earlier studies
- Kind of research
- A summary of earlier studies
The science
- Original title
- Targeting Specific Sirtuin Modulation: Emerging Therapeutic Strategies for Healthy Cognitive Ageing and Potential Implications for Alzheimer's Disease.
- Authors
- McDermott C, Cole MH, Pearson M et al.
- Journal
- Molecules (Basel, Switzerland)
- Published
- Oct 16, 2026
- Study type
- Review · in humans
- PMID
- 42883292 ↗
Abstract
Nicotinamide adenine dinucleotide (+)-dependent class III histone deacetylases, widely known as sirtuins (SIRTs), have been found to play key functions in a wide range of biological processes implicated in ageing processes. The downregulation of some specific SIRTs was reported in ageing and in some neurological diseases such as Alzheimer's disease. SIRT modulator factors, such as diet, exercise and various natural compounds, have recently emerged as a potential new avenue of therapy to modify the progression of Alzheimer's disease and delay some ageing effects. This review synthesises recent advances in the understanding of the modulatory effects of SIRTs in the context of healthy ageing with a particular focus on cognitive function and implications for Alzheimer's disease.
McDermott C, Cole MH, Pearson M et al. Targeting Specific Sirtuin Modulation: Emerging Therapeutic Strategies for Healthy Cognitive Ageing and Potential Implications for Alzheimer's Disease. Molecules (Basel, Switzerland). 2026. doi:10.3390/molecules31193528. PMID: 42883292. https://pubmed.ncbi.nlm.nih.gov/42883292/