What this means
Researchers followed 699 adults for up to 24 years and tracked how fast their aging clocks changed. People whose clocks sped up more were more likely to die. This study shows a link, not proof that the clock changes cause death.
Plain-English summary written by an AI model from the abstract. The original is below.
- Who it was tested in
- 699 adults from the InCHIANTI cohort
- Kind of research
- A study
The science
- Original title
- Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort.
- Authors
- Kuo PL, Moore AZ, Tanaka T et al.
- Journal
- Nature aging
- Published
- Mar 14, 2026
- Study type
- Study · in humans
- PMID
- 41826710 ↗
Abstract
Epigenetic clocks derived from DNA methylation patterns are among the most promising biomarkers of biological aging1-7, as they capture molecular signatures that predict morbidity and mortality beyond chronological age. Although cross-sectional assessments of epigenetic age have been linked consistently to health outcomes and lifespan, it remains unclear whether the rate of change in these clocks over time provides additional insight into aging trajectories. In this longitudinal study of 699 adults from the InCHIANTI cohort followed for up to 24 years, we evaluated whether temporal acceleration of several epigenetic clocks-including first-, second- and third-generation epigenetic clocks-was associated with mortality. We found that faster increases in several clocks were linked robustly to higher risk of death, independent of baseline epigenetic age and other confounders. These findings suggest that dynamic changes in epigenetic aging reflect evolving health status and may serve as sensitive indicators for interventions aimed at extending healthspan and longevity.
Kuo PL, Moore AZ, Tanaka T et al. Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort. Nature aging. 2026. doi:10.1038/s43587-026-01066-6. PMID: 41826710. https://pubmed.ncbi.nlm.nih.gov/41826710/