How people get it: Sold as a supplement.
Part of Age reversal: drugs and supplements studied for slowing aging
The basics
We're still gathering this from reference sources like the NIH and MedlinePlus. Sections appear here once every sentence is checked against its source.
What it is
Not enough reliable information yet.
How it's thought to work
Not enough reliable information yet.
What people use it for
Not enough reliable information yet.
What the research has found so far
On Alpha-ketoglutarate and aging, PubMed lists 1 trial in people, 1 studies that watched people over time, 114 animal and lab studies. See the counts and searches
Stage 2 because there are 1 published trial and 22 registered trials in people, but no large ones yet.
A stage shows how far research has got, not whether it will work for you. How stages work
Side effects and risks
Not enough reliable information yet.
Who should be careful, and drug interactions
Not enough reliable information yet.
What to expect: sessions, results and recovery
Not enough reliable information yet.
Amounts used in studies
What studies or labels describe, not a recommendation.
Not enough reliable information yet.
Roughly what it costs
The 5 products we list that contain Alpha-ketoglutarate cost from $24.98 to $99.95, as read from the makers' pages. See the products
Questions to ask your doctor
- Is Alpha-ketoglutarate a sensible option for me, given my health and the medicines I take?
- Could Alpha-ketoglutarate interact with any medicine or supplement I already take?
- What side effects should I watch for, and when should I stop or call you?
- Supplements aren't checked by the FDA before sale. Is there a brand or a third-party test seal you would trust?
- How would we tell whether it is helping, and when should we review it?
This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.
Products that contain it
Read from each maker's page. The research stage is for the ingredient, not proof that a product works.
| Product | Form | Alpha-ketoglutarate per serving | Price | Per serving |
|---|---|---|---|---|
| Calcium AKG Longevity Powder - 100 gramsProHealth Longevity · maker's page ↗ | powder | See labelserving: 1 Scoop (1.02 g) | $24.98100 servings | $0.25 |
| Calcium AKG Longevity - 1,000 mg per serving, 60 capsulesProHealth Longevity · maker's page ↗ | capsule | 180 mgserving: 2 Capsules | $25.2530 servings | $0.84 |
| CaAKGRenue By Science · maker's page ↗ | — | See label | $48.95 | — |
| Rejuvant® LifeAKG for MenRejuvant · maker's page ↗ | — | See label | $99.95 | — |
| Rejuvant® LifeAKG for WomenRejuvant · maker's page ↗ | — | See label | $99.95 | — |
Amounts, servings and prices are as each maker lists them on its own page, checked Oct 16, 2026. Price per serving is the price divided by the servings per container on the label; “—” means the page didn't say. A serving is the maker's serving size, not a recommendation.
What experts say
No expert views collected yet. Each one we add names the person and links to where they said it.
Recent research
New studies that mention Alpha-ketoglutarate appear here after the morning update.
Trials
None of the registered trials of Alpha-ketoglutarate is one we have linked as aging-related yet.
ClinicalTrials.gov lists 22 registered trials that mention Alpha-ketoglutarate, for any condition (the count in The science below). Here we show the ones about aging. See them all ↗
The science
Counted from PubMed and ClinicalTrials.gov on Oct 17, 2026, using one search for Alpha-ketoglutarate in relation to aging. Each link opens the exact search.
- Randomized trials in people
- 1 search ↗
- Large trials (multicenter or phase 3)
- 0 search ↗
- Phase 3 trials
- 0 search ↗
- Trials in people
- 1 search ↗
- Studies that watched people over time
- 1 search ↗
- Animal and lab studies
- 114 search ↗
- Registered trials
- 22 search ↗
PubMed search used
("alpha-ketoglutarate"[tiab] OR "alpha ketoglutarate"[tiab] OR "2-oxoglutarate"[tiab] OR "calcium alpha-ketoglutarate"[tiab]) AND (aging[tiab] OR ageing[tiab] OR longevity[tiab] OR lifespan[tiab] OR "life span"[tiab] OR healthspan[tiab] OR "Aging"[mh] OR "Longevity"[mh])
Counts are search results, so they include some records that only mention Alpha-ketoglutarate. How we count
Cite or share this page
Longevity Verdict. (n.d.). Alpha-ketoglutarate (Ca-AKG): Research stage and evidence. Retrieved October 17, 2026, from https://longevityverdict.com/treatments/alpha-ketoglutarate
<iframe src="https://longevityverdict.com/embed/stage/alpha-ketoglutarate" title="Alpha-ketoglutarate (Ca-AKG): research stage on Longevity Verdict" width="340" height="72" style="border:0" loading="lazy"></iframe>
The badge shows this treatment's current research stage and links back here. It updates by itself when the stage changes.