People
Metformin slowed frailty and lowered biological age in older adults
In a two-year trial, metformin slowed a frailty index score and lowered two blood-based aging clocks compared with placebo. The Fried frailty score showed no lasting difference once weight loss was removed, and the results do not show that metformin prevents frailty.
People
Metformin plus exercise and diet did not improve physical function in older adults with obesity
Researchers randomly assigned older adults with obesity to lifestyle changes, with or without metformin, or diet education with metformin. Adding metformin to intensive lifestyle changes did not improve physical function beyond lifestyle changes alone.