How people get it: Sold as a supplement, usually in capsules.
Part of Age reversal: drugs and supplements studied for slowing aging
The basics
What it is
NR is one of the NAD+ precursors, which are compounds the body can use to make NAD+.
What the research has found so far
- A review of studies found that oral NR raised NAD-related substances in blood or cells in humans.
- A review of studies found 2 human trials of NR in Alzheimer's disease that reported improvements in blood and brain imaging markers and in thinking tests.
- A review of studies found NR was linked to a longer walking distance in people with peripheral artery disease.
- The same review concluded that current evidence does not support NR for keeping muscle mass and function in adults over 60.
Sources: PubMed abstract: pubmed.ncbi.nlm.nih.gov ↗ · PubMed abstract: Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach. ↗ · PubMed abstract: pubmed.ncbi.nlm.nih.gov ↗
On NR and aging, PubMed lists 9 trials in people, 3 studies that watched people over time, 46 animal and lab studies. See the counts and searches
Stage 2 because there are 9 published trials and 127 registered trials in people, but no large ones yet.
A stage shows how far research has got, not whether it will work for you. How stages work
Side effects and risks
A review of studies found oral NR was generally well tolerated over weeks to months.
Roughly what it costs
The 17 products we list that contain NR cost from $17.97 to $116, as read from the makers' pages. See the products
Questions to ask your doctor
- Is NR a sensible option for me, given my health and the medicines I take?
- Could NR interact with any medicine or supplement I already take?
- What side effects should I watch for, and when should I stop or call you?
- Supplements aren't checked by the FDA before sale. Is there a brand or a third-party test seal you would trust?
- How would we tell whether it is helping, and when should we review it?
This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.
Products that contain it
Read from each maker's page. The research stage is for the ingredient, not proof that a product works.
| Product | Form | NR per serving | Price | Per serving |
|---|---|---|---|---|
| Tru Niagen® 300mgTru Niagen · maker's page ↗ | capsule | 300mgserving: 1 Vegetarian Capsule | $49.0090 servings | $0.54 |
| Nicotinamide Riboside + Pterostilbene - 30 capsulesProHealth Longevity · maker's page ↗ | capsule | 250 mgserving: 1 Capsule | $17.9730 servings | $0.60 |
| Nicotinamide Riboside Pro 300 + 100 mg TMG - 30 capsulesProHealth Longevity · maker's page ↗ | capsule | 300 mgserving: 1 Capsule | $24.9530 servings | $0.83 |
| Nicotinamide Riboside Pro 500 + 250 mg TMG per serving - 60 capsulesProHealth Longevity · maker's page ↗ | capsule | 500 mgserving: 2 Capsules | $25.1730 servings | $0.84 |
| NMNR™ Pro Synergy - 90 capsulesProHealth Longevity · maker's page ↗ | capsule | 500 mgserving: 3 Capsules | $35.9530 servings | $1.20 |
| NiaCel® 400Thorne · maker's page ↗ | capsule | 415mgserving: 1 Capsule(s) | $74.0060 servings | $1.23 |
| Tru Niagen® ImmuneTru Niagen · maker's page ↗ | capsule | See labelserving: 1 Vegetarian Capsule | $41.0030 servings | $1.37 |
| Tru Niagen® 150mgTru Niagen · maker's page ↗ | capsule | 150mgserving: 2 Vegetarian Capsules | $94.0060 servings | $1.57 |
| Tru Niagen® BeautyTru Niagen · maker's page ↗ | capsule | 100mgserving: 1 Vegetarian Capsule | $49.0030 servings | $1.63 |
| Nicotinamide Riboside Pro Complete - 500 mg NR Hydrogen Malate + 500 mg Trans-Resveratrol + 100 mg TMG per serving, 60 capsulesProHealth Longevity · maker's page ↗ | capsule | 500 mgserving: 2 Capsules | $49.9530 servings | $1.67 |
| Tru Niagen® 300mg Stick PacksTru Niagen · maker's page ↗ | stick pack | 300mgserving: 1 Packet (4g) | $58.0030 servings | $1.93 |
| ResveraCelThorne · maker's page ↗ | capsule | 415mgserving: 2 Capsule(s) | $60.0030 servings | $2.00 |
| Collagen PlusThorne · maker's page ↗ | — | 125mgserving: 1 Scoop(s) | $67.0030 servings | $2.23 |
| Tru Niagen® Pro 1,000mgTru Niagen · maker's page ↗ | capsule | 1000mgserving: 2 Vegetarian Capsules | $116.0030 servings | $3.87 |
| NAD+ Cell Regenerator™ and Resveratrol Elite™Life Extension · maker's page ↗ | capsule | 300 mgserving: 1 vegetarian capsule | $45.00 | — |
| Niagen NanoCloud™Tru Niagen · maker's page ↗ | stick pack | See label | $59.00 | — |
| BasisElysium Health · maker's page ↗ | — | See label | $65.00 | — |
Amounts, servings and prices are as each maker lists them on its own page, checked Oct 16, 2026. Price per serving is the price divided by the servings per container on the label; “—” means the page didn't say. A serving is the maker's serving size, not a recommendation.
What experts say
No expert views collected yet. Each one we add names the person and links to where they said it.
Recent research
New studies that mention NR appear here after the morning update.
Trials
None of the registered trials of NR is one we have linked as aging-related yet.
ClinicalTrials.gov lists 127 registered trials that mention NR, for any condition (the count in The science below). Here we show the ones about aging. See them all ↗
The science
Counted from PubMed and ClinicalTrials.gov on Oct 17, 2026, using one search for NR in relation to aging. Each link opens the exact search.
- Randomized trials in people
- 8 search ↗
- Large trials (multicenter or phase 3)
- 0 search ↗
- Phase 3 trials
- 0 search ↗
- Trials in people
- 9 search ↗
- Studies that watched people over time
- 3 search ↗
- Animal and lab studies
- 46 search ↗
- Registered trials
- 127 search ↗
PubMed search used
("nicotinamide riboside"[tiab]) AND (aging[tiab] OR ageing[tiab] OR longevity[tiab] OR lifespan[tiab] OR "life span"[tiab] OR healthspan[tiab] OR "Aging"[mh] OR "Longevity"[mh])
Counts are search results, so they include some records that only mention NR. How we count