What this means
This is a plan to study whether many health measures link to gene changes in blood, apart from age. It is still recruiting, so it does not yet show any results.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 50 and over
- Where
- 1 site, including Missouri
The science
- Registered title
- Aging, Geriatric Syndromes and Clonal Hematopoiesis
- Trial ID
- NCT02604563 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Geriatrics, Aged, Geriatric Syndromes, Cardiovascular Diseases
- What is tested
- Cognitive Assessment, Activities of Daily Living Questionnaire, Instrumental Activities of Daily Living, subscale of the OARS, Karnofsky Self-reported Performance Rating Scale, Number of Falls, Physical Health Section, subscale of the OARS, MOS Social Activity Survey, Unintentional Weight Loss, Peripheral Blood Draw, Buccal Swab, Heart Health and Smoking History from BRFSS questionnaire, Gait Speed, Grip Strength, Height and Weight measurements, Blood pressure measurement, Optional bone marrow biopsy, Blood draw for trauma measurements, Femur head donation, Knee bone fragments, Bone marrow aspirate
- Sponsor
- Washington University School of Medicine
- Ages
- 50 Years to no maximum
- Dates
- First posted Nov 13, 2015 · updated Jul 13, 2026
Registry summary
In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.
Sites (1)
- Washington University School of Medicine, St Louis, Missouri, United States