What this means
This is a plan to study whether a brain chemical called GABA links to balance and timing of senses. It has not started, so no results exist yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 20–80
- Where
- Not listed
The science
- Registered title
- The Role of GABA-mediated Inhibition in Multisensory Temporal Processing & Postural Control in Older Adults
- Trial ID
- NCT03328455 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Healthy Aging
- What is tested
- Inhibitory control training, Knowledge-based training
- Sponsor
- University of Nevada, Reno
- Ages
- 20 Years to 80 Years
- Dates
- First posted Nov 1, 2017 · updated May 1, 2026
Registry summary
In recent years evidence has accumulated on the association between age-related decline in multisensory temporal processing and postural control. This proposed project aims at examining GABA-mediated inhibition as the potential mechanism behind this link. Our overarching hypothesis is that changes in the excitatory-inhibitory balance with a reduction of GABAergic inhibition is a common mechanism underlying age-related multisensory and postural deficits potentially mediated by age-related reduction in network segregation. To test this hypothesis, we will assess the relationship between age-related multisensory/postural deficits and age-related reduction in GABA concentration in related brain areas and probe the role of GABA-mediated inhibition using cognitive training that specifically targets inhibitory functions. Our multimodal approach is innovative, and findings from this study has the potential to lead to the development of safe and effective rehabilitation protocols for older adults with impaired multisensory temporal integration and postural control.