What this means
This is a study that is still recruiting people, so no results are available yet. It aims to see how tau in the brain relates to thinking and memory, but it cannot yet show what tau does.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 55–90
- Where
- 1 site, including New York
The science
- Registered title
- Tau PET in Imaging and Cognition: Healthy Adults From 55-90
- Trial ID
- NCT03372317 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Mild Cognitive Impairment, Aging
- What is tested
- 18F-MK-6240
- Sponsor
- Yaakov Stern
- Ages
- 55 Years to 90 Years
- Dates
- First posted Dec 13, 2017 · updated Feb 11, 2026
Registry summary
The investigators aim to use the new PET radioligand, 18F-MK-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (MCI) elders. The investigators will then examine the interactions between differential tau burden and performance on cognitive tasks, functional magnetic resonance imaging (fMRI) neural activation patterns, and other cognitive and behavioral measures. By investigating these relationships, the investigators hope to understand the cognitive and behavioral outcomes of tau deposition found in specific brain regions in cognitively normal/mildly cognitively impaired adults. Furthermore, the study aims to examine how the presence of tau may contribute to the risk of subsequent cognitive decline, neurodegeneration, and dementia.
Sites (1)
- Columbia University Medical Center, New York, New York, United States