What this means
This study is recruiting people now and has not reported results yet. It aims to find brain changes that may come before memory and thinking decline.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60 and over
- Where
- 1 site, including California
The science
- Registered title
- Biomarker Exploration in Aging, Cognition and Neurodegeneration
- Trial ID
- NCT03860857 ↗
- Phase
- PHASE 3
- Study type
- interventional
- Conditions
- Alzheimer Disease, Cognitive Impairment, Cognitive Decline
- What is tested
- Amyloid PET scan, Tau PET scan using MK-6240, Neurocognitive testing, MRI
- Sponsor
- University of California, Irvine
- Ages
- 60 Years to no maximum
- Dates
- First posted Mar 4, 2019 · updated Jan 23, 2026
Registry summary
The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age. The investigators will test the usefulness of MRI, PET, and cognitive testing in detecting subtle changes in the brain that precede cognitive decline. An addendum to this study includes additional PET scans to examine the relationship between tau protein in the brain and cognitive decline. Tau is a protein that is known to form tangles in the areas of the brain important for memory, and these tau tangles are a hallmark of Alzheimer's disease. This sub-study research aims to look at the tau accumulation in the brain using an investigational drug called MK-6240, which is a radio tracer that gets injected prior to a positron emission tomography (PET) scan.
Sites (1)
- University of California, Irvine, Irvine, California, United States