What this means
This trial will expose skin of young and older adults to artificial UVB light and compare gene changes. It will also test whether a small IGF-1 injection makes older skin respond more like young skin.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 21 and over
- Where
- 1 site, including Ohio
The science
- Registered title
- Gene Expression Changes In Young and Geriatric Skin
- Trial ID
- NCT03932162 ↗
- Phase
- EARLY PHASE 1
- Study type
- interventional
- Conditions
- UVB Phototherapy Burn, Insulin-like Growth Factor 1, Aging
- What is tested
- Insulin-Like Growth Factor 1, No Insulin-Lie Growth Factor 1
- Sponsor
- Wright State University
- Ages
- 21 Years to no maximum
- Dates
- First posted Apr 30, 2019 · updated Feb 6, 2025
Registry summary
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
Sites (1)
- Wright State Physicians, Fairborn, Ohio, United States