What this means
This is a plan for a study that is still recruiting people, so no results exist yet. The researchers think chemotherapy may leave behind old cells that cause inflammation and later health problems.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–50
- Where
- 1 site
The science
- Registered title
- Senescence and the Early Ageing Phenotype After Chemotherapy for Testicular Cancer: the SEA-CAT Study
- Trial ID
- NCT04113122 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Testicular Cancer
- What is tested
- Skin biopsy, Subcutaneous fat biopsy
- Sponsor
- University Medical Center Groningen
- Ages
- 18 Years to 50 Years
- Dates
- First posted Oct 2, 2019 · updated Dec 13, 2024
Registry summary
Cisplatin-combination chemotherapy causes inevitably DNA damage by platinum-DNA adduct formation of both tumor cells but also healthy cells. It therefore stands to reason that testicular cancer treatment causes an increased burden of senescent cells, which causes upregulation of the SASP resulting in a pro-inflammatory phenotype. The investigators hypothesize that this may be an important mechanism behind development of late effects and an early ageing phenotype after treatment for testicular cancer.
Sites (1)
- University Medical Center Groningen, Groningen, Netherlands