What this means
This trial plans to compare tiny particles in fluid around eggs in younger and older women. It has not reported results, so it does not yet show what the particles do.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 20–45
- Where
- 1 site
The science
- Registered title
- Follicular Fluid Exosome miRNA During Oocyte Maturation
- Trial ID
- NCT04382872 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Oocyte Maturation
- Sponsor
- Chinese University of Hong Kong
- Ages
- 20 Years to 45 Years
- Dates
- First posted May 11, 2020 · updated Aug 13, 2025
Registry summary
Folliculogenesis involves the recruitment of primordial follicles into a group of growing follicles in which eventually one follicle is selected, matured and ovulated. Complex endocrine and intra-ovarian paracrine interactions occur to create a changing intra-follicular hormonal milieu suitable for oocyte development. However, this oocyte developmental competence and to undergo fertilization and embryogenesis is impaired in aged women. Diminished ovarian function is generally attributed to decreased quantity and quality of oocytes and their surrounding granulosa cells during ovarian aging, although the underlying mechanisms remain unclear.
The aim of the study is to investigate the miRNA in (follicular fluid) FF exosome in young and aged women and their relationship to egg maturation.
Sites (1)
- The Chinese University of Hong Kong, Hong Kong, Hong Kong