What this means
This is a plan for a study testing whether metformin, a diabetes drug, helps older people recover from burns. No results have been posted, so we do not yet know if it works.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 60–99 · Elderly burn patients (no number stated)
- Where
- 1 site
The science
- Registered title
- The Effects of Metformin on Morbidity and Mortality in Elderly Patients
- Trial ID
- NCT04530058 ↗
- Phase
- PHASE 2
- Study type
- interventional
- Conditions
- Burns
- What is tested
- Metformin, Placebos
- Sponsor
- Hamilton Health Sciences Corporation
- Ages
- 60 Years to 99 Years
- Dates
- First posted Aug 28, 2020 · updated Oct 2, 2024
Registry summary
Elderly patients have an increased susceptibility to burns and a substantial mortality that has not significantly changed over the last three decades. Elderly burn patients not only have an augmented response to burn but also express a prolonged hypermetabolic response.Glucose metabolism with insulin resistance is a hypermetabolic response pathway that profoundly affects post-burn outcomes. The aim if this study is to determine whether metformin can improve morbidity and mortality in elderly burn patients. The investigators hypothesize that metformin will improve clinical outcomes and mortality of elderly burn patients by alleviating the complex inflammatory and hypermetabolic responses after burn.
Sites (1)
- Hamilton Health Sciences Centre, Hamilton, Ontario, Canada