What this means
Researchers plan to count and study a type of immune cell in people who had COVID-19 and got better. The study is still enrolling, so no results have been posted yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Active not recruiting
- Who can join
- Ages 18–100
- Where
- 1 site, including Maryland
The science
- Registered title
- Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans
- Trial ID
- NCT04565067 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- COVID-19
- Sponsor
- National Institute on Aging (NIA)
- Ages
- 18 Years to 100 Years
- Dates
- First posted Sep 25, 2020 · updated Oct 13, 2026
Registry summary
Background:
The higher death rate from COVID-19 in the older population is associated with low CD8 T cell counts in the blood. Researchers want to learn the status of CD8 T cells specific to SARS-CoV-2 and their changes with aging and in COVID-19. This may help to identify why COVID-19 is particularly lethal in the elderly and help to create an effective vaccine against SARS-CoV-2 in the elderly.
Objective:
To identify SARS-CoV-2 specific CD8 T cells in humans, and to determine their quantity and quality in people who have recovered from COVID-19.
Eligibility:
Maryland residents age 18 and older who have tested positive for and recovered from COVID-19.
Design:
Participants will be screened by phone. They must be able to provide a copy of their positive COVID-19 test result.
Participants will visit the NIA/Clinical Research Unit. The visit will take about 1 hour.
Laboratory tests showing a positive COVID-19 result will be verified.
Participants vital signs will be checked. This will include blood pressure, temperature, pulse, and respiration. Height and weight will be measured.
Participants will have a medical history and medicine review. They will complete a COVID-19 questionnaire.
Participants will have blood drawn. They will give a urine sample.
Participants will give a saliva sample. They will rinse their mouth with water. After about 3 minutes, they will let saliva pool in the base of their mouth and then spit into a sterile container.
Participants may be asked if they would be willing to return for optional visits at about 4 months and 1 year later. They will repeat the same laboratory sampling performed at the first visit.
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Sites (1)
- National Institute of Aging, Clinical Research Unit, Baltimore, Maryland, United States