What this means
This trial is testing a short breathing exercise to see if it lowers blood pressure in adults with kidney disease. It has not reported results, so it does not yet show whether the exercise works.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 50 and over
- Where
- 1 site, including Colorado
The science
- Registered title
- Inspiratory Muscle Strength Training in Chronic Kidney Disease
- Trial ID
- NCT04911491 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Chronic Kidney Diseases, Hypertension, Aging, Blood Pressure
- What is tested
- IMST, Sham Training
- Sponsor
- University of Colorado, Denver
- Ages
- 50 Years to no maximum
- Dates
- First posted Jun 3, 2021 · updated May 2, 2025
Registry summary
More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control \<130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney disease. A stepwise combination of lifestyle modifications and drug therapy is recommended to lower blood pressure; however, adherence to time-intensive lifestyle interventions such as aerobic exercise in patients with chronic kidney disease is poor. This clinical trial seeks to establish the efficacy of high-resistance inspiratory muscle strength training, a novel time-efficient lifestyle intervention, for lowering systolic blood pressure and improving endothelial function in midlife and older adults with moderate-to-severe chronic kidney disease and inadequately controlled hypertension, and to use innovate translational assessments to understand the mechanisms involved.
Sites (1)
- University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States