What this means
This study will compare gum bacteria in older adults with and without Alzheimer's disease. It is still recruiting, so it does not yet show whether mouth bacteria are linked to the disease.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–90
- Where
- 1 site
The science
- Registered title
- Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
- Trial ID
- NCT05077618 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Periodontitis, Alzheimer Disease
- What is tested
- sampling of dental plaque and blood sample during the treatment
- Sponsor
- Centre Hospitalier Universitaire de Nice
- Ages
- 18 Years to 90 Years
- Dates
- First posted Oct 14, 2021 · updated Mar 20, 2025
Registry summary
The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority. This project is based on the assumption that the oral cavity represents a privileged observation space to address these issues. The mouth is a site of easy access for painless sampling; there is therefore a major interest in identifying early oral infectious markers of the development or evolution of senile dementia. In addition to the interest of an early oral diagnosis, the mapping of the oral microbial flora in the demented elderly would allow a better understanding, prevention or even control of the evolution of neurodegenerative diseases. The final objective of our approach is to characterize the oral pathogens, or more probably the group of oral pathogens, which are significantly associated with Alzheimer's disease.
Sites (1)
- CHU de Nice, Nice, CHU de NICE, France