What this means
This is a registered study that is still recruiting, so no results exist yet. It will track gut bacteria and frailty signs in people with HIV over time.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 55 and over
- Where
- 1 site
The science
- Registered title
- Microbiota Footprint and Frailty Phenotype in Virologically Suppressed People Living With HIV
- Trial ID
- NCT05078957 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- HIV Infections
- What is tested
- Stool sampling, Frailty phenotype, Blood plasma collection
- Sponsor
- Hôpital Européen Marseille
- Ages
- 55 Years to no maximum
- Dates
- First posted Oct 15, 2021 · updated Sep 25, 2025
Registry summary
Analysis of gut microbiota becomes more and more accessible in recent years. Experimental data in both animal and human studies have demonstrated that imbalance of the gut microbiota which is called symbiosis may participate in an accelerated procedure of ageing as well as the expression of frailty phenotype. People living with HIV (PLHIV) present markers of phenotypic frailty on average 10 years before uninfected people.
In this population structural and functional modifications of GALT (Gut Associated Lymphoid Tissue) are observed early after HIV infection and persist despite virological suppression on ART (AntiRetroviral Treatment). These GALT modifications are associated with microbial translocation that is also correlated with immune activation and dysbiosis.
The objective of study is to explore gut microbiota of PLWH over 5 years, as well as to study associations of its longitudinal evolution with frailty markers and burden of comorbidities.
Sites (1)
- Hôpital Européen Marseille, Marseille, France