What this means
This is a plan to study bone marrow and blood samples from people having hip surgery. It has not started reporting results, so it cannot yet tell us what the cells show.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 55 and over
- Where
- 1 site
The science
- Registered title
- Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
- Trial ID
- NCT05246813 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Osteoporosis, Osteoarthritis, Hip, Hip Fractures, Clonal Hematopoiesis of Indeterminate Potential, Aging
- What is tested
- Blood and bone marrow cell collection
- Sponsor
- Imelda Hospital, Bonheiden
- Ages
- 55 Years to no maximum
- Dates
- First posted Feb 18, 2022 · updated Mar 25, 2026
Registry summary
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.
Sites (1)
- Imelda Hospital, Bonheiden, België, Belgium