What this means
This is a plan to test whether weight lifting and endurance exercise raise blood markers of bone breakdown. It does not yet show what the results will be, because the study has not reported any.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60 and over
- Where
- 1 site, including Colorado
The science
- Registered title
- Mode of Exercise and Bone Biomarkers in Older Veterans
- Trial ID
- NCT05266976 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Aging, Musculoskeletal Diseases, Osteoporosis
- What is tested
- 10 Weeks of Supervised Resistance Exercise Training, 10 Weeks of Supervised Endurance Exercise Training
- Sponsor
- VA Office of Research and Development
- Ages
- 60 Years to no maximum
- Dates
- First posted Mar 4, 2022 · updated May 22, 2026
Registry summary
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.
Sites (1)
- Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado, United States