What this means
This is a plan for a study that has not finished yet. It has no results, so it cannot yet show whether the nutrition plan helps.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 75 and over
- Where
- 1 site
The science
- Registered title
- Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.
- Trial ID
- NCT05324475 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Malnutrition, Sarcopenia
- What is tested
- BCAA, Micronutriments, standard treatment + placebo
- Sponsor
- Patrizia D'Amelio
- Ages
- 75 Years to no maximum
- Dates
- First posted Apr 12, 2022 · updated May 31, 2025
Registry summary
Aging is associated with an increased inflammation named "inflammageing" and with an altered immune response. Different mechanisms have been proposed to explain the phenomenon of inflammageing and increased oxidative stress: deficiencies in essential amino acids, and some micronutrients have an important impact and may induce immune cell dysregulation. Mitochondrial dysfunction may explain the complex relationship between malnutrition sarcopenia, immune dysfunction and aging.
Therefore, a personalized nutritional strategy aiming to improve mitochondrial function, decrease oxidative stress, down-regulate inflammation and restore immunity appears to be a logical approach in order to treat malnutrition and its biological and clinical consequences.
MIMOSA will investigate the role of nutritional supplements in rescuing altered mitochondrial function and redox state imbalance.
Sites (1)
- CHUV, Lausanne, Switzerland, Switzerland