What this means
Researchers plan to follow older adults who eat small amounts and compare them with others over one year. The study will look for links between gut bacteria, nutrition, thinking and movement, but it has not reported results yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 75 and over
- Where
- 1 site
The science
- Registered title
- Loss of Autonomy in the Elderly: Relationships Between Gut Microbiota Diversity, Nutrition and Cognitive and Sensory-motor Disturbances in "Small Eaters" and "Non Small Eaters"
- Trial ID
- NCT05449119 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Elderly Small Eater
- What is tested
- Fecal and blood sampling and collection of nutritional, cognitive and sensorimotor data, Body Mass Index (BMI), 24-hour food and beverage record, Mini Nutritional assessment (MNA), Measurement of muscle mass by bioelectrical impedance analysis (except for participants with a pacemaker), Measurement of sensorimotor functions, Measurement of cognitive functions
- Sponsor
- Centre Hospitalier Universitaire Dijon
- Ages
- 75 Years to no maximum
- Dates
- First posted Jul 8, 2022 · updated Aug 15, 2024
Registry summary
Older adults currently make up 25% of the population in France, and future health expenditures will be largely related to the consequences of aging. Normal aging is associated with a progressive decrease in cognitive and sensorimotor function, malnutrition and/or under-nutrition and intestinal dysbiosis (i.e. changes in the composition and/or stability of the microbiota). Furthermore, admission to long-term care facilities such as Etablissement d'Hébergement pour Personnes Agées Dépendantes (EHPAD) leads to drastic changes in lifestyle in terms of (i) nutrition and (ii) motor functions. These modifications can influence the composition of the intestinal microbiota and its temporal evolution.
We will study the relationship between the deterioration of cognitive and sensorimotor function, diet and intestinal well-being (i.e. microbiota) of a cohort of older adults (>75 years) defined as "small eaters" from their admission in EHPAD at the University Hospital of Dijon. This study will be carried out by a unique French multidisciplinary consortium that includes academics and health professionals, who will be able to specify the criteria defining the "small eaters" and to envisage suitable dietary strategies aiming to preserve their nutritional status and intestinal well-being. The final goal is to improve quality of life at home by prolonging autonomy and independence, and thus to deferring admission to an EHPAD for as long as possible.
The objective of this study is to build a cohort of elderly "small eaters" and a cohort of elderly "non small eaters". These patients will be followed over a period of one year. The evolution of the composition of the intestinal microbiota will be determined in order to establish the existing relations between the composition of digestive microbiota, the nutritional state, and cognitive and sensorimotor function.
Sites (1)
- Chu Dijon Bourgogne, Dijon, France