What this means
This is a plan to test whether brain training with scanner feedback can change how older adults learn trust. It does not show any results yet, so we cannot know if it works.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–100
- Where
- 1 site, including Florida
The science
- Registered title
- Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging
- Trial ID
- NCT05457725 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Aging, Cognitive Change, Neurocognitive Disorders, Mild
- What is tested
- Contingent rtfMRI neurofeedback training, Non-contingent/sham rtfMRI neurofeedback training
- Sponsor
- University of Florida
- Ages
- 18 Years to 100 Years
- Dates
- First posted Jul 14, 2022 · updated Sep 23, 2026
Registry summary
Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly underlying the dramatically growing public health problem of elder fraud. Optimal trust-related decision making and avoiding exploitation require the ability to learn about the trustworthiness of social partners across multiple interactions, but the role that learning plays in determining age deficits in trust decisions is currently unknown.
Aim: Probe the malleability of the underlying neurocircuitry of trust-learning deficits in aging. This study will utilize real-time fMRI neurofeedback to train older adults in brain activity up-regulation toward enhanced trust-related learning in aging and confirm critical mechanisms of experience-dependent social decisions in aging.
Grant R01AG072658 Aim 3: Test the malleability of trust-learning neurocircuitry toward optimized trust-related decision making in aging.
Sites (1)
- University of Florida, Gainesville, Florida, United States