What this means
This is a plan to use magnetic pulses on the brain to see if they help working memory. It is still recruiting people, so no results are available yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–75
- Where
- 1 site, including North Carolina
The science
- Registered title
- Neuromodulation of Memory in Aging
- Trial ID
- NCT05460468 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Mild Cognitive Impairment, MCI
- What is tested
- Transcranial Magnetic Stimulation
- Sponsor
- Indiana University
- Ages
- 18 Years to 75 Years
- Dates
- First posted Jul 15, 2022 · updated Aug 11, 2026
Registry summary
The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.
Sites (1)
- Duke University Hospital, Durham, North Carolina, United States