What this means
Researchers plan a trial of short, hard exercise bouts for older veterans. The trial has not reported results, so it does not yet show whether the exercise helps.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 65 and over
- Where
- 2 sites, including Missouri
The science
- Registered title
- High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
- Trial ID
- NCT05625204 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Frailty
- What is tested
- Center based attention (stretching only) control, Center based HIIT, Home based HIIT
- Sponsor
- VA Office of Research and Development
- Ages
- 65 Years to no maximum
- Dates
- First posted Nov 22, 2022 · updated Dec 12, 2025
Registry summary
Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, defined as the capacity to recover from disruptions to homeostasis, is critical to successful aging because it precedes frailty and enhances adults' ability to maintain optimal health and function well into older age. Evidence- based therapies to help older adults enhance resilience are limited and the biological underpinnings contributing to improved resilience have not yet been fully characterized. To address this important need, the investigators will conduct a clinical trial to examine the benefits of center- and home-based high intensity interval training (HIIT) on functional capacity, frailty, and resilience, and also to identify novel biomarkers of resilience in older Veterans.
Sites (2)
- Kansas City VA Medical Center, Kansas City, MO, Kansas City, Missouri, United States
- Kansas City VA Medical Center, Kansas City, MO, Kansas City, Missouri, United States