What this means
This is a trial plan for a 12-week study of a supplement called HMB in older adults. It has not started reporting results yet, so it does not show whether HMB helps.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 65–85
- Where
- 1 site, including North Carolina
The science
- Registered title
- Precision Medicine and Physical Function
- Trial ID
- NCT05877846 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Frailty, Weakness, Muscle, Multiple Chronic Conditions
- What is tested
- Beta-hydroxymethyl butyrate supplement, Vitamin D supplement, Matching Beta-hydroxymethyl butyrate supplement without Vitamin D
- Sponsor
- University of North Carolina, Chapel Hill
- Ages
- 65 Years to 85 Years
- Dates
- First posted May 26, 2023 · updated Feb 17, 2026
Registry summary
The investigators aim to conduct a 12-week, single-arm, pre/post-intervention of b-hydroxy-methylbutyrate in persons aged 65 to 85 years to assess feasibility and acceptability of the intervention and study procedures, secondary outcomes of physical function and changes in multi-omics patterns, and exploratory outcomes that will allow the team to describe physical function phenotype. The investigators' primary outcomes are the: feasibility of the study procedures (including safety), feasibility of the intervention delivery, and acceptability of study procedures and measures. Secondary outcomes include: Objective and subjective physical function measures that predict disability including the 30-second sit-to-stand, knee strength, isokinetic strength, grip strength, gait speed, 400-m walk test, Pittsburgh Fatiguability, PROMIS global health-10, social support, anthropometry, National Institutes of Health (NIH) Cognitive toolbox, Automated Self-Administered 24-hour Dietary Assessment (ASA-24), Community Healthy Activities Model Programs (CHAMPS), Ultrasound Imaging, Magnetic Resonance Imaging (MRI), Changes in untargeted metabolomic profile data based on qualitative or semiquantitative analysis of the most probable detectable metabolites in laboratory samples , Discover potential metabolites that explain changes in physical function using a discovery science, precision medicine approach (discovery science approach that is exploratory)
Sites (1)
- University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
