What this means
This study will test how well people smell in a remote, app-based test. Researchers want to see if smell can help predict brain disorders, but no results are reported yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–100
- Where
- 1 site, including Massachusetts
The science
- Registered title
- Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
- Trial ID
- NCT05881239 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
- What is tested
- AROMHA Brain Health Test
- Sponsor
- Massachusetts General Hospital
- Ages
- 18 Years to 100 Years
- Dates
- First posted May 31, 2023 · updated Mar 6, 2026
Registry summary
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched controls. The main question it aims to answer is whether the AROMHA Brain Health Test could serve as a predictive biomarker of neurodegenerative disorders. This understanding will aid in the development of a noninvasive, cost-effective diagnostic tool that reliably and specifically distinguishes disease and normal aging populations.
Participants will take the approximately 45-minute AROMHA Brain Health Smell Test where they will peel and sniff labels on the physical smell cards and answer questions on the web-based app relating to what they smelled. Participants will undergo tests for odor intensity, odor identification, odor discrimination, and episodic olfactory memory, but will not be provided the results of these tests.
Sites (1)
- Massachusetts General Hospital, Boston, Massachusetts, United States