What this means
This trial compared repeat eye injections of foselutoclax with aflibercept, a standard treatment. The trial has finished and posted results, but this summary does not say what they showed.
Plain-English summary written by an AI model from the registry listing.
- Status
- Completed
- Who can join
- Ages 18 and over
- Where
- 19 sites, including California, Colorado, Florida
The science
- Registered title
- Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE)
- Trial ID
- NCT06011798 ↗
- Phase
- PHASE 2
- Study type
- interventional
- Conditions
- Diabetic Macular Edema, Retinal Disease, Macular Edema, Diabetes Mellitus, Diabetic Retinopathy, Retinal Degeneration, Retinal Diseases, Eye Diseases, Edema
- What is tested
- Aflibercept, foselutoclax
- Sponsor
- Unity Biotechnology, Inc.
- Ages
- 18 Years to no maximum
- Dates
- First posted Aug 25, 2023 · updated Aug 5, 2025
Registry summary
The goal of this clinical trial is to assess the efficacy and safety of multiple doses of foselutoclax (UBX1325) in patients with Diabetic Macular Edema. The main questions the study aims to answer are:
- Assess the efficacy of foselutoclax compared to aflibercept
- Assess the safety and tolerability of foselutoclax
Sites (19)
- California Retina Consultants, Bakersfield, California, United States
- Retina-Vitreous Associates Medical Group, Beverly Hills, California, United States
- Salehi Retina Institute Inc., Huntington Beach, California, United States
- Bay Area Retina Associates, Walnut Creek, California, United States
- Advanced Vision Research Institute, Longmont, Colorado, United States
- Rand Eye Institute, Deerfield Beach, Florida, United States
- Florida Eye Associates, Melbourne, Florida, United States
- Retina Vitreous Associates of Florida, St. Petersburg, Florida, United States
- University Retina and Macula Associates, Lemont, Illinois, United States
- Midwest Eye, Carmel, Indiana, United States
- Cumberland Valley Retina Consultants, Hagerstown, Maryland, United States
- Sierra Eye Associates, Reno, Nevada, United States
- EyeHealth Northwest, Portland, Oregon, United States
- Erie Retina Research, LLC, Erie, Pennsylvania, United States
- Vision Research Solutions, PLLC, Philadelphia, Pennsylvania, United States
And 4 more on the listing.
More aging trials in these states
California · Colorado · Florida · Illinois · Indiana · Maryland · Nevada · Oregon · Pennsylvania · South Carolina · Texas