What this means
This is a trial that has not reported results yet. It will test whether dexmedetomidine, a sedating drug, helps older people live longer after cancer surgery.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60 and over
- Where
- 39 sites
The science
- Registered title
- Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
- Trial ID
- NCT06030804 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Elderly, Cancer Surgery, Dexmedetomidine, Long-Term Survivors
- What is tested
- Dexmedetomidine, Placebo
- Sponsor
- Peking University First Hospital
- Ages
- 60 Years to no maximum
- Dates
- First posted Sep 11, 2023 · updated Jul 31, 2025
Registry summary
Along with aging population, cancer incidence and mortality are increasing. However, despite advances in oncology and surgery, long-term survival of cancer patients is far from optimal. Dexmedetomidine is a highly selective alpha 2 adrenergic receptor agonist with sedative, analgesic, and anxiolytic effects. Studies showed that perioperative use of dexmedetomidine reduces delirium and some non-delirium complications after surgery. In long-term follow-up studies of older patients who, for other reasons, were randomized to receive either dexmedetomidine or placebo during intra- or postoperative period, dexmedetomidine use was associated with improved long-term survival. This multicenter randomized trial aims to investigate the effect of perioperative dexmedetomidine on long-term outcomes in older patients undergoing cancer surgery.
Sites (39)
- The First Affiliated Hospital of China University of Science and Technology, Hefei, Anhui, China
- The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui, China
- Peking University First Hospital, Beijing, Beijing Municipality, China
- Tsinghua University Yuquan Hospital, Beijing, Beijing Municipality, China
- Cancer Hospital Chinese Academy of Medical Sciences, Beijing, Beijing Municipality, China
- The First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing, Chongqing Municipality, China
- Fujian Provincial Hospital, Fuzhou, Fujian, China
- The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
- Fujian Medical University Union Hospital, Fuzhou, Fujian, China
- Jinjiang City Hospital (Shanghai Sixth People's Hospital, Fujian Hospital), Jinjiang, Fujian, China
- Guangdong General Hospital, Guangzhou, Guangdong, China
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
- The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China
- The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
- Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, China
And 24 more on the listing.