What this means
Researchers plan to measure how much threonine adults over 60 need. Right now the amount is based only on studies of young adults, so this trial may help fill that gap.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60–90
- Where
- 1 site
The science
- Registered title
- Threonine Requirement in Adults >60 Years of Age
- Trial ID
- NCT06225648 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Healthy, Aging
- What is tested
- threonine
- Sponsor
- The Hospital for Sick Children
- Ages
- 60 Years to 90 Years
- Dates
- First posted Jan 26, 2024 · updated May 30, 2025
Registry summary
Threonine is an essential amino acid and must be obtained from the diet. The body's capacity to maintain adequate mucin synthesis is directly related to the bioavailability of certain amino acids, including threonine, serine and proline (1). Moreover, the rate of mucin synthesis has been demonstrated to be directly related to the availability of dietary threonine in healthy rats (2) and piglets (3,4). Intestinal inflammation is known to increase gastrointestinal threonine uptake and mucin synthesis in enterally fed minipigs (5). Additionally, in animals, mucin function/barrier has been shown to decline with age, leaving them more susceptible to bacterial penetration. Thus, with advancing age (6), a higher dietary supply of threonine may be needed for maintaining intestinal mucosal health. Despite this, the current threonine requirement is based on studies conducted exclusively in young adults. Thus, there is a need to determine the threonine requirement directly in older adults.
Sites (1)
- The Hospital for Sick Children, Toronto, Ontario, Canada