What this means
This is a trial that is recruiting people, so no results have been posted yet. It tests whether a gentler treatment can work as well as the usual one with fewer long-term side effects.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 65–99 · Older adults with HPV-linked throat cancer (no number stated)
- Where
- 1 site, including Florida
The science
- Registered title
- Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
- Trial ID
- NCT06309225 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Oropharynx Cancer, Frailty
- What is tested
- Modified dose and fields intensity modulated radiotherapy
- Sponsor
- Omar Mahmoud
- Ages
- 65 Years to 99 Years
- Dates
- First posted Mar 13, 2024 · updated Sep 29, 2026
Registry summary
Previous studies of this type of head and necl cancer have shown high rates of cancer control but result in many short and long term side effects when treated with high dose radiation and chemotherapy. Recently, investigators have noticed similar high rates of cancer control in small numbers of patients who receive less intensive treatments using lower doses of radiation, smaller radiation fields with chemotherapy. It is expected that the side effects of treatment with lower doses of radiation would be less.
For this reason this study is looking at a different regimen of reducing the intensity of the treatment.
The purpose of this study is to compare any good and bad effects of using lower dose smaller fields radiation therapy and chemotherapy with published outcomes. This study will allow the researchers to know whether these different approaches are better, the same, or worse than the usual approach. To be better, the study approach should result in the same survival rate of the usual approach (about 85 out of 100 patients alive and free of cancer at 2 years) but with less long-term side effects.
Sites (1)
- Baptist MD Anderson Cancer Center, Jacksonville, Florida, United States