What this means
Researchers plan to give some older adults psilocybin and scan their brains over time. This is a trial that is still recruiting, so no results are available yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60–85
- Where
- 1 site, including California
The science
- Registered title
- Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
- Trial ID
- NCT06367738 ↗
- Phase
- PHASE 1
- Study type
- interventional
- Conditions
- Aging
- What is tested
- Psilocybin
- Sponsor
- University of California, Berkeley
- Ages
- 60 Years to 85 Years
- Dates
- First posted Apr 16, 2024 · updated Oct 21, 2025
Registry summary
Participants in this study will undergo a series of non-invasive tests and activities designed to understand how a single dose of psilocybin might influence cognition and emotional well-being in healthy older adults. After providing written informed consent, eligible participants, aged between 60 and 85, will be randomly assigned to receive a dose of psilocybin ranging from a microdose to a moderate-to-high dose. Anatomical magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) will be used to assess changes in brain structure, while functional magnetic resonance imaging (fMRI) will be used to quantify changes in functional brain activity.
Sites (1)
- University of California, Berkeley, Berkeley, California, United States