What this means
This study will test whether a daily ketone supplement helps strength and wellness in adults over 65 with slight decline. It is still recruiting, so no results exist yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 65 and over
- Where
- 3 sites, including California, Connecticut, Ohio
The science
- Registered title
- Targeting Aging With a Ketone Ester for Function in Frailty
- Trial ID
- NCT06645847 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Frail Elderly, Aging, Immune Function, Muscle Function
- What is tested
- Ketone ester, Placebo Comparator: Non-ketone placebo
- Sponsor
- Buck Institute for Research on Aging
- Ages
- 65 Years to no maximum
- Dates
- First posted Oct 17, 2024 · updated Sep 9, 2026
Registry summary
This study aims to find out if a food supplement that contains a naturally occurring substance, ketones, can help to improve strength and general wellness in adults at, or over the age of 65 years who are experiencing a slight decline in their physical function.
Participation will involve a screening visit and 4 additional study visits over the course of 20 weeks. After being assessed for eligibility, study participants will be sorted into two groups at random and consume either a ketone or placebo supplement at home every day for 20 weeks. Both study products can cause gastro-intestinal side effects in some individuals. At all study visits, subjects will provide blood samples. At three study visits, subjects will be asked to complete physical performance tests, provide blood, stool and urine samples. They will also complete questionnaires during three study visits to assess physical function, markers of inflammation, and other aspects of general well-being.
The study enrolls at three sites across the United States, in California (Buck Institute), Ohio (Ohio State University), and Connecticut (University of Connecticut). The study is coordinated by the San Francisco Coordinating Center (California Pacific Medical Center).
Sites (3)
- Buck Institute for Research on Aging, Novato, California, United States
- UConn Health, Farmington, Connecticut, United States
- Ohio State University, Columbus, Ohio, United States