What this means
This study plans to test whether short cycles of low and high oxygen breathing affect heart, lungs, and blood pressure. It has not started, so it cannot yet show any effects.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 65–90
- Where
- Not listed
The science
- Registered title
- Effects of Intermittent Hypoxia-Hyperoxia in Older Adults
- Trial ID
- NCT06686316 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Sedentary Behavior, Frailty, Older Adults
- What is tested
- Device: Hypoxic Gas Mixture, Sham Hypoxic-Hyperoxic exposure
- Sponsor
- Sierra Varona SL
- Ages
- 65 Years to 90 Years
- Dates
- First posted Nov 13, 2024 · updated Nov 27, 2024
Registry summary
The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with reduced oxygen fraction, controlled through a specific software, using a facial mask and a hypoxic generation device. The objective of this study is to determine if there is a relationship between intermittent hypoxia-hyperoxia exposure and cardiorespiratory condition, blood pressure, and arterial oxygen saturation.
According to our hypothesis, acute IHHE in elderly adults may influence cardiorespiratory condition, inflammatory biomarkers, blood pressure, and arterial oxygen saturation.
The study will be conducted as a randomized clinical trial. The subjects will be divided into two groups: the experimental group will undergo an IHHE session, breathing air with an oxygen concentration (FiO2) ranging from 10-14% for 1-5 minutes, with 1-3 minutes of rest in hyperoxia (FiO2 30-40%) for a total of 4-8 cycles, based on their acute response to hypoxia. The sham group will undergo a 5-cycle protocol with an FiO2 of 21%.
Both groups will follow a 6-week protocol with three weekly sessions (Monday, Wednesday, and Friday).