What this means
This is a planned study that is still signing up people, so no results exist yet. It will look at how estrogen levels affect how older women's bodies respond to heat.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 42–64
- Where
- 1 site, including Pennsylvania
The science
- Registered title
- Role of Menopause in Thermoregulation
- Trial ID
- NCT06798571 ↗
- Phase
- PHASE 4
- Study type
- interventional
- Conditions
- Menopause, Aging
- What is tested
- Elagolix Oral Tablet, Estradiol patch, cellulose placebo, placebo patch
- Sponsor
- Penn State University
- Ages
- 42 Years to 64 Years
- Dates
- First posted Jan 29, 2025 · updated Oct 2, 2026
Registry summary
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men.
Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.
Sites (1)
- Noll Laboratory, University Park, Pennsylvania, United States