What this means
This is a planned study that has not started collecting patient information yet. It will test whether a body process linked to inflammation is tied to frailty in older people waiting for a kidney transplant.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 70 and over
- Where
- 3 sites
The science
- Registered title
- Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation
- Trial ID
- NCT06887075 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Chronic Kidney Failure, Frailty, Aging, Inflammation
- What is tested
- Blood sample, Geriatric assessment standardized
- Sponsor
- University Hospital, Bordeaux
- Ages
- 70 Years to no maximum
- Dates
- First posted Mar 20, 2025 · updated Mar 20, 2025
Registry summary
Kidney transplantation (KT) benefit-risk ratio assessment is a challenge in a growing population of older patients with end-stage kidney disease. A pre-KT frailty phenotype has been found predictive of post-KT complications, but biological mechanisms of frailty are poorly known is these patients. Frailty is associated with chronic low-grade inflammation in the older general population, possibly through the inflammasome pathway. Our main objective is to assess if systemic activation of inflammasomes is associated with frailty in older candidates to KT.
Sites (3)
- CHU de Bordeaux - Hôpital Pellegrin -, Bordeaux, France, France
- CHU de Bordeaux, Hôpital Xavier Arnozan- Gérontologie Clinique, Pessac, France, France
- CHU de Toulouse - Hôpital Rangueil, Toulouse, France, France