What this means
This trial will test whether a drug called ABBV-CLS-628 is safe and works for adults with a kidney cyst disease. It has not reported results yet, so we cannot tell if it helps.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–55 · About 240 adults with ADPKD, at about 100 sites worldwide
- Where
- 60 sites, including Alabama, California, Connecticut
The science
- Registered title
- ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
- Trial ID
- NCT06902558 ↗
- Phase
- PHASE 2
- Study type
- interventional
- Conditions
- Autosomal Dominant Polycystic Kidney Disease
- What is tested
- ABBV-CLS-628, Placebo
- Sponsor
- Calico Life Sciences LLC
- Ages
- 18 Years to 55 Years
- Dates
- First posted Mar 30, 2025 · updated Oct 6, 2026
Registry summary
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of kidney disease that causes fluid-filled cysts to develop in the kidneys. The purpose of this study is to assess the safety and efficacy of ABBV-CLS-628 for the treatment of ADPKD in adult participants.
ABBV-CLS-628 is an investigational drug being developed for the treatment of ADPKD. Participants are placed in 1 of 4 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 4 chance that participants will be assigned to placebo. Around 240 adult participants with ADPKD will be enrolled at approximately 100 sites worldwide.
Participants will receive IntraVenous ABBV-CLS-628 or placebo every 4 weeks for 92 weeks. Participants will be followed for up to 15 weeks.
There may be higher treatment burden for participants in this trial compared to their standard of care . Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Sites (60)
- University of Alabama at Birmingham, Birmingham, Alabama, United States
- Valiance Clinical Research - Huntington Park, Huntington Park, California, United States
- Academic Medical Research Institute (AMRI) - Los Angeles, Los Angeles, California, United States
- UC Irvine Medical Center, Orange, California, United States
- National Institute of Clinical Research - Pomona, Pomona, California, United States
- University Of California, San Francisco, San Francisco, California, United States
- University of California Los Angeles Medical Center, Santa Monica, California, United States
- Yale University School of Medicine, New Haven, Connecticut, United States
- Horizon Research Group - Coral Gables, Coral Gables, Florida, United States
- South Florida Research Institute, Fort Lauderdale, Florida, United States
- Nature Coast Clinical Research - Inverness, Inverness, Florida, United States
- Mayo Clinic Hospital Jacksonville, Jacksonville, Florida, United States
- Panax Clinical Research, Miami, Florida, United States
- University of Miami Don Suffer Clinical Research Building, Miami, Florida, United States
- Infigo Clinical Research, Sanford, Florida, United States
And 45 more on the listing.
More aging trials in these states
Alabama · California · Connecticut · Florida · Georgia · Idaho · Illinois · Iowa · Kansas · Massachusetts · Michigan · Minnesota · Missouri · New York · North Carolina · Pennsylvania · South Carolina · Tennessee · Texas · Washington