What this means
This is a trial that is recruiting people, so no results are posted yet. It will test whether creatine helps muscle, strength, and movement after knee surgery.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 65 and over
- Where
- 1 site
The science
- Registered title
- Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty
- Trial ID
- NCT06925880 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Sarcopenia in Elderly, Frailty at Older Adults, Functional Capacity, Creatine Supplementation, Arthroplasties, Knee Replacement, Physical Performance
- What is tested
- Creatine Monohydrate, Placebo
- Sponsor
- Consorci Sanitari del Maresme
- Ages
- 65 Years to no maximum
- Dates
- First posted Apr 13, 2025 · updated Mar 30, 2026
Registry summary
Double-blind randomized placebo-controlled clinical trial with two parallel arms. The main objective is to evaluate the efficacy and safety of creatine supplementation in older adults who have been operated on for total knee arthroplasty and undergoing a usual rehabilitation program. The intervention will consist of daily creatine monohydrate supplementation for 12 weeks. The intervention will start after surgery with a loading dose of 20g/day for 1 week and then continue with a maintenance dose of 5g/day for 11 weeks.
Main outcome mesures included muscle mass, muscle strenght, sarcopenia, frailty, functional capacity and physical performance and will be assessed at baseline, 3 and 6 months follow-up.
Sites (1)
- Elisabet Palomera, Mataró, Barcelona, Spain