What this means
This is a planned trial that has not started recruiting or reported any results yet. It will compare a new type of brain stimulation with an older method and a fake treatment.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 21–75
- Where
- Not listed
The science
- Registered title
- Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults
- Trial ID
- NCT06991764 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Transcranial Direct Current Stimulation (tDCS), Ageing, Executive Functioning, Transcranial Electric Stimulation
- What is tested
- Non-Invasive Brain Stimulation (tDCS / tPCS / sham-tPCS)
- Sponsor
- Nanyang Technological University
- Ages
- 21 Years to 75 Years
- Dates
- First posted May 28, 2025 · updated May 28, 2025
Registry summary
The goal of this randomised controlled trial is to investigate the effects of a 2-week high-frequency transcranial pulsed current stimulation (tPCS) on cognitive outcomes in older and healthy adults. The main questions it aims to answer are:
- Would a single session of anodal tPCS over the left prefrontal cortex improve working memory, task inhibition, and task switching in healthy young and older adults, compared to anodal transcranial direct current stimulation (tDCS) and sham-tPCS?
- Would repeated session of anodal-tPCS (2-weeks) lead to improvements in working memory, task inhibition, and task switching in healthy young and older adults, compared to tDCS and sham-tPCS?
- Will tPCS be better tolerated among healthy adults, compared to tDCS?
Researchers will compare tPCS / tDCS / sham-tPCS to see if there are any differences in cognitive outcomes after 1 session and after repeated sessions, as well as to compare the tolerance of tPCS against tDCS and sham-tPCS.
Participants will be requested to:
- Undergo 1 of 3 of the following conditions: tDCS / tPCS / sham-tPCS
- Complete three sessions of cognitive tasks testing working memory, inhibition and task switching at baseline (pre-stimulation), after day 1 of brain stimulation and after 10 sessions of brain stimulation (post- repeated stimulation)
- Undergo fNIRS-EEG brain measurements concurrently with the cognitive tasks