What this means
This study is looking at whether sickle cell trait may raise the risk of thinner bones. It also checks muscle strength and frailty in older women with and without the trait.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 50 and over · 50 women aged 50 or older, planned
- Where
- 1 site, including Connecticut
The science
- Registered title
- Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
- Trial ID
- NCT07083531 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Sickle Cell Disease, Sickle Cell Trait
- What is tested
- Healthy volunteers without SCT, Healthy volunteers with SCT
- Sponsor
- UConn Health
- Ages
- 50 Years to no maximum
- Dates
- First posted Jul 24, 2025 · updated Jul 24, 2025
Registry summary
This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators estimate enrolling 50 female volunteers who are at least 50 years old and have not had a menstrual period for at least 12 consecutive months. Volunteers need not know whether they have SCT as this will be evaluated as part of the study.
Sites (1)
- UConn Health, Farmington, Connecticut, United States