What this means
This is a trial plan for older adults that is still recruiting people. No results have been posted, so we cannot yet know whether ketone esters change aging cells or inflammation.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 65–80
- Where
- 1 site
The science
- Registered title
- Effects of Ketone Esters on Circulating Senescent T Lymphocytes (T Cells) and Inflammation Levels in the Elderly
- Trial ID
- NCT07087093 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- The Elderly
- What is tested
- Ketone ester
- Sponsor
- First Affiliated Hospital of Harbin Medical University
- Ages
- 65 Years to 80 Years
- Dates
- First posted Jul 25, 2025 · updated Jul 25, 2025
Registry summary
Studies have shown that aging can promote a variety of pathological processes, such as myocardial remodeling and cardiac dysfunction caused by ischemia-reperfusion injury and pressure load. Previous studies found that the level of circulating beta-hydroxybutyric acid decreased significantly with age. It has been reported that the ketogenic diet reduces the occurrence of tumors and neurodegenerative diseases in mice, improves motor coordination and endurance, and ultimately extends life span. Current research results have confirmed that ketone bodies have multiple mechanisms to exert beneficial effects on cardiovascular diseases. However, the effect of age-related cardiovascular disease has not been reported.
In order to further clarify the role of beta-hydroxybutyric acid in age-related cardiovascular diseases, find new intervention targets for elderly cardiovascular diseases, and develop new effective prevention and treatment measures for elderly cardiovascular diseases. We will further investigate this hypothesis by establishing a clinical cohort of the elderly population.
Sites (1)
- the First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China