What this means
This trial will compare everolimus, weight-style exercise, both together, and dummy pills in women aged 60 to 75. It has not reported results, so it does not yet show whether any of these help bone or muscle.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60–75 · Postmenopausal women aged 60-75 in a planned trial; no participant count stated
- Where
- 2 sites
The science
- Registered title
- Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women
- Trial ID
- NCT07191353 ↗
- Phase
- PHASE 2
- Study type
- interventional
- Conditions
- Healthy, Osteopenia, Osteoporosis Risk
- What is tested
- Everolimus, Placebo, Resistance training
- Sponsor
- Odense University Hospital
- Ages
- 60 Years to 75 Years
- Dates
- First posted Sep 24, 2025 · updated Apr 6, 2026
Registry summary
The aim of the present clinical trial is to examine the effects of everolimus, resistance training, or their combination on bone and muscle health formation in elderly women aged 60-75 years. The main questions it aims to answer are:
Can rapamycin's analog (Everolimus), resistance training, or their combination, enhance bone formation and muscle functions in elderly women compared to non-treatment controls.
Participants will be randomized 1:1:1:1 to one of the following treatment regimens:
- Oral everolimus 5 mg once a week.
- Oral placebo once a week.
- Oral everolimus 5 mg once a week plus resistance training RT 1 hour, 3 times weekly.
- Oral placebo once a week plus resistance training RT 1 hour, 3 times weekly.
During the study there will be a total of 5-7 visits, where the participants will undergo the following:
- Blood samles
- DXA-, HRpQCT- (only Odense Universitetshospital) and MRI-scans
- Muscle- and bone biopsies
- Quality of life questionnaires
- Testing of muscle funtion
- Metabolic studies of muscle and bone protein turnover using labelling with deuturated water
Sites (2)
- Institute of Sports Medicine, Bispebjerg Hospital, Bispebjerg, Region Sjælland, Denmark
- Department of Endocrinology, Odense University Hospital, Odense, Region Syddanmark, Denmark