What this means
This study will compare usual care with usual care plus 12 weeks of strength training. It will look at aging markers, such as telomere length, and other health measures. The study has not started recruiting, so no results are available yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 18 and over · People aged 18 to 35 with a first psychotic episode, in Salamanca, Spain
- Where
- Not listed
The science
- Registered title
- Physical Exercise in Patients With First Psychotic Episode
- Trial ID
- NCT07207538 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Telomere Length, Exercise, First Episode Psychosis (FEP)
- What is tested
- Other: Strength physical exercise programme, Other: Normal life
- Sponsor
- University of Salamanca
- Ages
- 18 Years to no maximum
- Dates
- First posted Oct 6, 2025 · updated Oct 6, 2025
Registry summary
Justification: Patients with first-episode psychosis are at increased risk of premature ageing and early mortality, associated with telomere shortening and increased inflammatory markers. Physical exercise has shown protective effects in the general population, but there are no intervention studies in this population.
Objective: To evaluate the effect of a strength training programme on telomere length and other markers of cellular ageing in people with a first episode of psychosis.
Material and methods: Quasi-experimental study with patients aged 18-35 years included in the PRINT programme (Salamanca). Standard treatment will be compared with standard treatment plus a 12-week strength training programme. Telomere length (qPCR), inflammatory and senescence markers (proteomics), body composition, frailty and quality of life will be analysed.
Applicability: The results could support the inclusion of physical exercise programmes as a complementary intervention in early psychosis care, promoting overall health, quality of life and reducing the gap in life expectancy compared to the general population.