What this means
This trial is testing whether different amounts of carbon dioxide can safely move proteins from the brain into the blood. Researchers see this as a sign the brain may clear waste better, but no results have been posted yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–82
- Where
- 1 site, including New Mexico
The science
- Registered title
- Carbon Dioxide Administration and Brain Waste Clearance
- Trial ID
- NCT07357090 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Traumatic Brain Injury, Aging Disorder, Magnetic Resonance Imaging (MRI)
- What is tested
- Hypercapnia task performed during fMRI
- Sponsor
- Andrew Mayer
- Ages
- 18 Years to 82 Years
- Dates
- First posted Jan 21, 2026 · updated Oct 6, 2026
Registry summary
The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a counter-balanced design, in which individuals with and without a history of traumatic brain injury (TBI) will receive different levels of CO2 (targeted changes of approximately 5 or 10 mmHG in end-tidal CO2) approximately one week apart. The counter-balanced design means that each participant receives a single dose of CO2 at each visit, and different doses of CO2 at each visit. The order in which participants receive the dose is randomized, and the participant will not be informed of the dose.
Sites (1)
- The Mind Research Network, Albuquerque, New Mexico, United States