What this means
This is a plan for a study that has not started yet. It will test whether a nerve treatment eases migraine pain and headache days in older adults.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 65 and over
- Where
- Not listed
The science
- Registered title
- Treatment Response to GON Pulsed Radiofrequency in Elderly Patients With Chronic Migraine
- Trial ID
- NCT07363083 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Headache, Migraine
- Sponsor
- Ankara City Hospital Bilkent
- Ages
- 65 Years to no maximum
- Dates
- First posted Jan 23, 2026 · updated Feb 10, 2026
Registry summary
Headache disorders are highly prevalent in older adults, yet their management remains challenging due to comorbidities, polypharmacy, and the paucity of evidence derived from geriatric populations. Most randomized clinical trials exclude elderly patients, underscoring the need for effective and safe non-pharmacological treatment strategies for headache in this age group.
Greater occipital nerve blocks are commonly used in the treatment of migraine and other headache disorders; however, their clinical benefit is often transient. Pulsed radiofrequency (PRF) has been introduced as a minimally invasive technique aimed at prolonging therapeutic effects through neuromodulation without causing structural neural damage. Although greater occipital nerve pulsed radiofrequency (GON-PRF) has demonstrated efficacy in various headache disorders, its effectiveness in patients aged 65 years and older has not been adequately investigated.
The primary aim of this study is to evaluate the effectiveness of GON-PRF in patients aged ≥65 years with chronic migraine by assessing changes in pain intensity, monthly headache days, and monthly severe headache days. The secondary aim is to identify geriatric predictors of treatment response, including frailty status and the Geriatric Nutritional Risk Index (GNRI), in order to support individualized treatment strategies for older adults.