What this means
This is a planned study that has not started enrolling people yet. It will test whether immune cells and inflammation are linked to how much anesthesia older patients need.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 18 and over · Planned study of older and younger adults having major abdominal surgery; no participants yet
- Where
- 1 site
The science
- Registered title
- Macrophage/Monocyte Driven Inflammation and Anesthetic Sensitivity in Aging
- Trial ID
- NCT07372417 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Aging, Inflammation, Blood-Brain Barrier Permeability, Anesthesia Brain Monitor, Anesthesia Depth Monitoring, Inflammation Biomarkers, Inflammaging, Monocyte
- Sponsor
- University of Chile
- Ages
- 18 Years to no maximum
- Dates
- First posted Jan 28, 2026 · updated Jan 28, 2026
Registry summary
The goal of this observational study is to determine whether macrophage/monocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery. The main questions it aims to answer are:
- Is there a difference in anesthetic dosing requirements (minimum effective dose) between young and older patients undergoing major abdominal surgery?
- How do electroencephalographic (EEG) signatures under anesthesia correlate with age and systemic inflammatory markers?
- Is there an association between age, levels of circulating inflammatory cytokines, and monocyte/macrophage phenotypes with anesthetic requirements?
If there is a comparison group: Researchers will compare older adult patients undergoing major abdominal surgery to younger adult patients undergoing major abdominal surgery to see if macrophage/monocyte-mediated inflammatory signaling influences anesthetic sensitivity and the risk of postoperative neurocognitive complications in the older population.
Participants will:
- Receive general anesthesia for major abdominal surgery, with continuous recording of anesthetic dose requirements.
- Undergo electroencephalographic (EEG) monitoring during the anesthetic period.
- Provide blood samples for the measurement of circulating inflammatory cytokines and the assessment of monocyte phenotypes.
- Provide peritoneal tissue samples (collected during surgery) to evaluate tissue macrophage populations.
- Provide cerebrospinal fluid (CSF) samples to assess biomarkers of blood-brain barrier permeability.
Sites (1)
- Hospital Clínico Universidad de Chile, Santiago, Santiago Metropolitan, Chile