What this means
This is a plan for a study that will give people HMB, 2-HOBA, both, or a comparison supplement. It will check muscle strength, thinking skills, and safety. No results have been posted yet, so we do not know if either supplement helps.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 65 and over
- Where
- 1 site
The science
- Registered title
- This Study Investigates β-hydroxy-β-methylbutyrate (HMB) and 2-hydroxybenzylamine (2-HOBA), When Administered Either Individually or in Combination Contributes to an Increased Quality of Health, Specifically Improving Muscular Strength and Cognitive Functioning in Adults Over the Age of 65.
- Trial ID
- NCT07419633 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Muscle, Cognitive Functioning, Geriatric, Ageing and Geriatric Health, Ageing
- What is tested
- β-Hydroxy-β-methylbutyrate, 2-hydroxybenzylamine, β-Hydroxy-β-methylbutyrate and 2-hydroxybenzylamine, Placebo
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Ages
- 65 Years to no maximum
- Dates
- First posted Feb 19, 2026 · updated May 14, 2026
Registry summary
In this study, participants will be assigned to receive HMB, 2-HOBA, a combination of both, or a comparison supplement for a set period of time. During the study, participants will attend scheduled visits where researchers will assess muscle strength, physical function, and overall health. Blood samples may be collected to measure markers related to metabolism, inflammation, and oxidative stress. Study staff will also monitor safety and any side effects throughout the study.
Sites (1)
- RI-MUHC, Montreal, Quebec, Canada