What this means
This is a plan for a trial that has not started yet. It would test whether walking and strength exercise, with or without computer brain games, helps balance, thinking, and falls.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 55–85
- Where
- 1 site, including Georgia
The science
- Registered title
- Exercise With and Without Cognitive Training
- Trial ID
- NCT07447115 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Multiple Sclerosis
- What is tested
- Effect of Exercise with and Without Cognitive Training on Gait
- Sponsor
- VA Office of Research and Development
- Ages
- 55 Years to 85 Years
- Dates
- First posted Mar 3, 2026 · updated Mar 3, 2026
Registry summary
This proposal aims to conduct a 10-week randomized controlled trial comparing walking and resistance training with and without computerized cognitive training in older Veterans with Multiple Sclerosis, followed by 12 months of fall tracking with sensors and fall calendars. The primary objectives of this proposed CDA2 are to provide critical preliminary data on 1) the feasibility of conducting a 10-week RCT, 2) preliminary treatment effects on gait, cognition, and falls, and 3) neuroinflammatory biomarkers. Dr. Katherine Hsieh will receive hands-on training in the design and conduct of clinical trials (Dr. Hackney), mechanisms underlying physical activity, cognitive rehabilitation, and falls (Drs. Twamley, Hackney, \& Kesar), fall detection technology (Prof. Sanford), and clinical problems faced by MS participants (Dr. Backus) to achieve her long-term career goal of becoming an independent falls prevention investigator.
Sites (1)
- Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia, United States