What this means
This trial will test whether creatine pills plus strength training help muscle and physical function in men on hormone therapy. It has not reported results, so it does not yet show whether it works.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 40 and over
- Where
- 1 site
The science
- Registered title
- Creatine Supplementation and Resistance Training to Improve Sarcopenia Parameters in Patients With Prostate Cancer After Androgen Deprivation Therapy
- Trial ID
- NCT07463092 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Prostate Cancer, Sarcopenia
- What is tested
- Creatine Monohydrate, Maltodextrin, Resistance training
- Sponsor
- University of Sao Paulo
- Ages
- 40 Years to no maximum
- Dates
- First posted Mar 10, 2026 · updated Jun 11, 2026
Registry summary
This randomized, double-blind, placebo-controlled clinical trial will investigate the effects of creatine supplementation combined with a 12-week supervised resistance training program on muscle mass, muscle strength, physical performance (e.g., parameters of sarcopenia), and muscle density in men with prostate cancer undergoing androgen deprivation therapy (ADT). ADT often causes loss of lean mass, reduced muscle strength, functional impairment, and increased fat mass. Eligible male patients will be randomly assigned to receive either creatine monohydrate or a placebo (maltodextrin) in a double-blind manner, in addition to participating in the resistance exercise program. Assessments will be performed at baseline and after the 12-week intervention period and will include:
- Muscle density and architecture assessed by ultrasound
- Body composition (lean mass and fat mass)
- Muscle strength
- Physical performance (functional performance tests)
- Inflammatory biomarkers
- Vascular function parameters
The primary goal is to assess whether creatine supplementation combined with resistance training can safely improve muscle quality and quantity, strength, and physical function in these patients. If effective and safe, the intervention could help reduce muscle loss and improve quality of life in men undergoing ADT.
Sites (1)
- School of Physical Education and Sport - USP, São Paulo, São Paulo, Brazil