What this means
This trial plans to test whether a 12-week exercise program lowers liver fat, inflammation and scarring. It has not started recruiting, so no results exist yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 40 and over
- Where
- 1 site
The science
- Registered title
- Exercise for an Aging Liver (EXALIVER)
- Trial ID
- NCT07467512 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASH - Metabolic Dysfunction-Associated Steatohepatitis, Liver Fibrosis/NASH
- What is tested
- Exercise, Usual Care
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
- Ages
- 40 Years to no maximum
- Dates
- First posted Mar 12, 2026 · updated Mar 12, 2026
Registry summary
The goal of this clinical trial is to learn how physical exercise affects liver health in adults with metabolic dysfunction-associated steatotic liver disease (MASLD) or at-risk metabolic dysfunction-associated steatohepatitis (MASH); comparing responses between middle-aged adults (40-60 years old) and older adults (70 years and older) of any sex, as well as between participants with low-risk MASLD and high-risk MASH. The main question it aims to answer is:
Could an exercise program reduce liver fat, inflammation and fibrosis, regardless of age and disease severity?
Researchers will compare 4 different groups:
A) older adults with at risk MASH who will exercise B) middle-aged people with at risk MASH who will exercise C) middle-aged people with low-risk MASLD who will exercise D) middle-aged people with low-risk MASLD who will not exercise, receiving usual care.
Participants in the exercise groups will take part in a supervised 12-week exercise program that includes both strength and aerobic training, completed twice a week.
All participants, including those receiving usual care, will have health asssessments before and after the 12-week period to measure changes in liver health.
Sites (1)
- Hospital General Universitario Gregorio Marañon, Madrid, Spain