What this means
This trial plans to compare a geriatric care plan with usual cancer treatment alone. It has not started recruiting, and no results have been posted yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 70 and over
- Where
- 24 sites
The science
- Registered title
- Geriatric-guided Care Versus Conventional Care in Elderly Unfit/Frail Patients With Diffuse Large B-cell Lymphoma in First Line Treatment
- Trial ID
- NCT07476105 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Diffuse Large B Cell Lymphoma, Follicular Lymphoma Grade 3B
- What is tested
- Geriatric-guided supportive care, Conventional supportive care
- Sponsor
- Fondazione Italiana Linfomi - ETS
- Ages
- 70 Years to no maximum
- Dates
- First posted Mar 17, 2026 · updated Apr 15, 2026
Registry summary
The aim of this multicenter, non-randomized, cluster controlled trial study is to evaluate the impact of a geriatric-guided approach with a pro-active rehabilitative/nutritional plan for elderly unfit/frail DLBCL patients eligible for receiving chemoimmunotherapy according to the sGA, versus a conventional approach with onco-hematological treatment alone.
A key innovation element of this project is to use a geriatric-guided approach to improve the global management of all frailty aspects (nutritional, functional, cognitive, social), chasing a better tolerance and completion rate of treatment, tailoring safety and efficacy of therapies in unfit/frail DLBCL patients.
This study may lead to a personalized approach for elderly DLBCL patients, taking into account a multidisciplinary and fully-integrated program, with the primary aim of improving the quality of life of patients and their families.
Sites (24)
- Azienda Ospedaliero Universitaria delle Marche - S.O.D. Clinica Ematologica, Ancona, Italy
- A.O.R.N. S. Giuseppe Moscati - S.C. Ematologia e Trapianto emopoietico, Avellino, Italy
- I.R.C.C.S. Centro di Riferimento Oncologico - S.O.C. Oncologia medica e dei tumori immuno-correlati, Aviano, Italy
- I.R.C.C.S. Istituto Tumori Giovanni Paolo II - U.O.C. Ematologia, Bari, Italy
- A.S.S.T. Spedali Civili - S.C. Ematologia, Brescia, Italy
- A.R.N.A.S. "Brotzu" P.O. Businco - S.C. Ematologia e TMO, Cagliari, Italy
- A.O.U. Careggi - S.O.D. Ematologia, Florence, Italy
- A.S.S.T. Grande Ospedale Metropolitano Niguarda - S.C. Ematologia, Milan, Italy
- I.R.C.C.S. Fondazione Cà Granda Ospedale Maggiore Policlinico - S.C. Ematologia, Milan, Italy
- I.R.C.C.S. Fondazione San Gerardo dei Tintori - S.C. Ematologia, Monza, Italy
- I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncologia 1, Padova, Italy
- A.O.U. Policlinico "Paolo Giaccone" - U.O.C. Ematologia, Palermo, Italy
- Azienda Ospedaliero Universitaria di Parma - S.C. Ematologia e C.T.M.O., Parma, Italy
- A.U.S.L. di Piacenza Osp. Guglielmo da Saliceto - U.O.C. Ematologia e Centro Trapianti, Piacenza, Italy
- Azienda USL Toscana Centro - SOS Oncoematologia, Prato, Italy
And 9 more on the listing.